25% life extension? 'Nature' sub-journal discovers new substances, which is expected to open the era of 'long survival'

"If I can live another 30 years, I am willing to exchange it with 100 billion." In fact, not only the rich man Lee Shau Kee, but people have been looking for "longevity" since Qin Shihuang. From the once miraculous elixir to the help of modern technology, the mystery of longevity is constantly being unraveled.

At the beginning of this month, scientists in Istanbul published an article in the "Nature" sub-journal: They discovered a new substance that reduces the risk of cancer and prolongs the median life expectancy by about 25%.

1. Discover the anti-aging "new star": M47

M47 is one of 200 proteins that bind to cryptochrome (CRY), the "switch" that regulates the body's diurnal changes. Unlike other proteins, M47 negatively affects the production of cells, especially cancer cells.

In the experiment, the researchers first injected M47 molecules into the abnormal cells (pre-cancerous), and found that the abnormal cells rushed there before they remembered to "go bad". Based on this data, the experimenters targeted cancer-prone lab mice.

In the experiment, male mice were injected with 50MG/kg of M47 molecules, and after 7 consecutive weeks, it was pleasantly discovered that not only the risk of cancer was reduced, but the median survival period of the mice was extended from 24 weeks to 29.5 weeks, which was prolonged by 25%.

The conclusion of this experiment surprised the team, and another "longevity switch" was discovered.

The research team conducted further safety tests. It was found that there may be certain risks in the early stages of use, but no adverse reactions occurred in the next few days, and the follow-up team may conduct further research.

2. Usher in the anti-aging "spring": a variety of molecules have been discovered

In fact, it is not just M47. Since Harvard biologists first broke the deadlock and discovered the anti-aging molecule NAD+ in 2013, many related molecules have been discovered.

For example, the PCC1 discovered by the Chinese Academy of Sciences in anthocyanin prolongs the survival of mammals by 64.2%; the natural metabolite AKG discovered by Kennedy, an anti-aging national teacher in Singapore, intervenes for 7 months and 8 months; The extract was found to prolong life by 37%-41%...

With the continuous development of science and technology, the results have blossomed in many ways. Among them, the above-mentioned molecules first discovered by biologist David have achieved phased results. In the past 9 years, from animal experiments to clinical trials, it has now stepped out of the laboratory and produced "ruoanti" experimental results.

Citing the clinical trials conducted by the Chinese Academy of Sciences and the Guangzhou Institute of Physical Education in the first half of this year, middle-aged and elderly subjects aged 45-65 underwent the above-mentioned molecular interventions, and the indicators of skeletal muscle, aging cells, and skin tissue were reversed to varying degrees, which has an effect on slowing down aging. It must be positive. Qingbei Life Joint Center also published a paper, confirming that it also has the potential to intervene in the heart.

Scientific research creates a "golden body". Relying on the continuous clinical data, it objectively promotes the landing of experimental results. Among them, "Ruofan" developed by Chinese scientists for more than ten years, with the patented enzymatic technology, improves the purity to 99% on the basis of foreign products, and takes the lead in opening up the domestic market.

While radiating more than 100,000 users on JD.com, it was once spread to overseas markets, and also attracted David, the discoverer of the core substance. He disclosed in "cell" that the raw materials used in the experiment were provided by "Ruofan": through multiple rounds test, only if it passes the experimental review criteria.

As a substance discovered earlier, after more than 9 years of research, the current experiments still have problems such as small samples and no control group. In the future, more experimental data still need to be carried out, and there is a long way to go.

3. "Our goal is the sea of ​​stars"

"In 2020, medical knowledge will double every 73 days, and a biotechnology revolution is coming," analysts at Bank of America Merrill Lynch wrote. With the continuous maturity of biotechnology, not only molecules are blooming in many ways, but also more and more technologies are coming.

For example, Israeli scientists discovered a hyperbaric oxygen chamber, and a 65-year-old man took oxygen for 90 days to return to his 25-year-old age; Bezos, the world’s richest man, invested 20 billion to focus on gene reprogramming; Paypal founder Peter Thiel chose "exchange blood"; there are even some Horrific cryosurges, head swaps, and more.

"Longevity" never lacks suitors.

But it has to be admitted that with the advancement of science and technology, the average life expectancy of human beings has undergone a qualitative leap. It took only 50 years to go from an average age of 40 to almost 80 today. An era of "long survival" may be opening.