breakthrough! U.S. scientists discover 'young molecules' from ginger that remove 50% of senescent cells in 2 days

Do you have the habit of drinking ginger soup?

Ginger soup has been regarded as a "longevity" ingredient since ancient times. Confucius revealed that he was a fan of ginger in the "Analects of Confucius", "don't eat ginger, don't eat too much", which means "eat a little at every meal", and later lived to 73 years old when the average life expectancy was less than 35 years old.

There is also a folk saying "Eating three slices of ginger early is better than ginseng soup", and women comrades even regard ginger soup as a "secret recipe for maintenance". In modern times, the research of scientists has "pushed ginger soup to the altar". Ginger contains some mysterious substance that can make people return to youth.

In May 2022, the National Institute on Aging (NIA) published a paper in the international journal "Plos One", announcing the discovery of two "rejuvenating" molecules in ginger, 6-shogaol and zingerenone A, which can reverse aging , removes up to 50% of senescent cells within 2 days.

Why does removing senescent cells reverse aging? According to the data, senescent cells are the "source of pollution" of the human body, which will infect surrounding healthy cells. If the aging cells can be found and removed at the first time, the aging tissues can be "rejuvenated" to a certain extent.

Therefore, the senescent cell removal technique was rated as "one of the 7 major anti-aging methods" by the "Science" journal in 2020, and it also attracted the world's richest man, Bezos, to invest 2 billion US dollars to establish the Altos anti-aging laboratory to study "precise removal of aging techniques". ".

In the field of senescent cell removal, the traditional combination of D+Q (dasatinib and quercetin) is the preferred choice. Although the effect is outstanding, it will "disadvantage the pond fish" - while removing senescent cells, it will also destroy healthy cells.

In this experiment, the researchers set D+Q as a control group and found that 40% of the senescent cells in the body were successfully removed after 48 hours. Unfortunately, the division of healthy cells is inhibited. The disadvantages of the combination of D+Q appear, which proves that it is not the safest and most effective way to remove.

In the ginger experimental group, the researchers treated senescent cells with two ginger extracts respectively. After 48 hours, it was found that the effect of 6-shogaol was similar to the combination of D+Q, which would damage healthy cells while removing senescent cells; however, the effect of shogaol A excited the research team, not only having no effect on healthy cells , its effect is also better than the traditional combination of D+Q, up to 50%. As a daily visible ingredient, if ginger is widely used, it means that the aging process of human beings is expected to be delayed or even reversed.

Can the treasure extract hidden in ginger knock on the door of human longevity? At this stage, it is difficult to give a definite answer. The research team said the next step would be to conduct human clinical trials.

In fact, removing senescent cells is not the only way to intervene in the human aging process. David Sinclair, deputy director of the Harvard Center for Aging Research, once pointed out, "Instead of passively waiting for the formation of senescent cells, it is better to actively prevent cell aging and fundamentally achieve youthfulness. ."

Adhering to the concept of "preventing aging", after 20 years of research, Sinclair finally discovered a "Celere" type of young molecule in the experiment, which can activate cell activity, selectively remove senescent cells, and prolong mammalian life. 30% lifespan. Because of this discovery, Professor Sinclair was selected by Time Magazine as one of the "100 Most Influential People in the World" and became recognized as the "Godfather of Anti-aging".

Later, Sinclair took the molecule himself and mobilized the whole family to participate. He took his younger brother as a control group, ingesting only saline, and took himself, his father and a dog as an experimental group. After a year of intervention and sequencing of the methylation clock, the 51-year-old Sinclair was only 31.5 years old. His father was walking on the ground in the mountaineering TV show "Wind Speed ​​Cross Country", unlike an 80-year-old man at home. The spirit of the old dog has also become more vigorous.

After Sinclair's "anecdote" was disseminated by the academic circles, major colleges and universities organized human clinical trials. Institutions of higher learning such as the University of Washington, the University of Tokyo, and the Royal Swedish Academy have followed suit, organizing 30 middle-aged and elderly volunteers with an average age of 53 to take the "Selori" type of young molecules. After 3 months of intervention, the subjects' cell activity, telomere length and testosterone levels and other elderly indicators had positive effects to varying degrees. In the follow-up return visit, some volunteers turned their white hair into blue silk, and some happily expressed that "the husband and wife are more loving".

With the support of hard-core scientific research, it has promoted Japan, which has the most serious aging, and took the lead in transforming it into a "Selori" supplement. In recent years, it has been popular all the way from Ginza in Japan to JD.com in China. In the recent Double 11 shopping boom, although the threshold for a single bottle is as high as one apple, it is still included in the repurchase list by high-income people. The person in charge of its brand surnamed Wang said: Most of the users are high-net-worth individuals aged 35-55, and their core demands are to increase energy and satisfy sleep.

Zingerone A, which is found in ginger, is more affordable and can also remove aging cells. If it passes the next clinical stage, it will undoubtedly have a broader application prospect than the former.

In 1905, when the average life expectancy was less than 40 years old, bioimmunologist Arthur McFarney predicted in "The Golden Age of Extending Life": "Modern science will bring immortality to the elderly."

Today, the ever-blooming life sciences seem to be accelerating the arrival of predictions. China's aging rate is 18.7%, and 260 million elderly people are thinking about this day.