Scientists in Singapore discovered that 'natural youth factor', 7 months younger and 8 years younger, is hidden in the body

Scientific and technological progress has produced many achievements that help people relieve pain and cure diseases, but most of them are chemically synthesized substances with more or less side effects. Therefore, now many scientists are starting to look at nature, trying to protect the body with the power of pure natural substances.

Professor Brian Kennedy, head of the International Anti-aging Dana and Buck Institute on Aging, is one of them.

As early as 2014, Professor Kennedy published research results in the top journal "Nature": exogenous supplementation of a pure natural substance called AKG can prolong life by 50%. This research shocked the scientific community. Now this research has ushered in a new breakthrough. Professor Kennedy published an article in the authoritative journal "Aging": taking 7 months of AKG supplements can reduce the physiological age of experimental participants by 8 years!

1, 7 months, 8 years younger

AKG, the full name is α-ketoglutaric acid, is an endogenous substance in the human body, a precursor of an important energy-supplying substance ATP, and a synthetic substrate of amino acids. It can generate energy and synthesize essential proteins for the human body, thereby improving mitochondrial function. , enhance cell repair ability.

However, with the increase of age, the body's ability to absorb AKG gradually declines, which affects the physiological activities of normal cells and causes cells to age, which is one of the important reasons for aging.

Previously, Professor Brian Kennedy has confirmed in animal experiments that supplementing AKG can prolong the survival period of aged animals by 5-10%, increase energy by 50%, and optimize aging indicators such as hair quality and hair loss. Time, skip the ill period when the quality of life drops sharply before S death.

In order to further explore the performance of AKG in humans, Professor Kennedy conducted a clinical trial and invited 42 volunteers (28 males and 14 females) with an average age of 63 years to participate. DNA methylation detection technology found that the average biological age of the volunteers was 8 years younger!

Professor Kennedy also emphasized: "AKG is a real substance that can safely prolong human health. A large number of experiments have shown that even taking a large dose of 6 grams of AKG a day will not affect health, and before the life-extending effect was discovered, AKG has been used by bodybuilders. , athletes have used it as a muscle-building supplement for many years.”

2. Who can bear the side effects?

AKG is now FDA-approved as a safe dietary supplement. However, in the process of promotion, some problems have also been found, because AKG can only be absorbed by gastrointestinal cells, which can easily cause absorption and metabolic pressure in the gastrointestinal tract, and many users have side effects such as nausea, abdominal distension, vomiting and diarrhea. .

The scientific research results were originally intended to make people live better, but as a result, they aggravated the discomfort in life, which is a bit of putting the cart before the horse. But fortunately, anti-aging scientific research results are diverse, and there are other options.

In the paper "The Quest to Slow Ageing Through Drug Discovery", Professor Kennedy also summarized and analyzed the anti-aging achievements in recent years, and rated them according to indicators such as life-extending effect, degree of side effects, and toxicity. In addition to AKG, the professor himself also agrees with the substance called β-nicotinamide (the scientific and technological achievements are translated as "Ruohui"). What's more, the substance has had little feedback of side effects during the years of marketization.

It is reported that β-nicotinamide was developed by Harvard Medical School. As early as 2013, it was confirmed in authoritative journals such as "Nature" and "Cell" that it can reverse the aging indicators of mitochondria, telomeres, and DNA recovery enzymes in aging organisms, and shorten the survival time. Lengthen about 30%. Moreover, compared with AKG, the research scope of β-nicotinamide is wider, and foreign Harvard, MIT, domestic Chinese Academy of Sciences, Qingbei, Tongji, etc. have all involved, and no obvious side effects were found in the experiments.

On the other hand, when searching mainstream consumer websites, there are very few AKG supplements, and there are few admirers, but the finished product of β-nicotinamide "Ruohui" is blooming everywhere, starting with hundreds of thousands of people in JD.com and other channels. ". It is reported that during important events such as Double 11, the sales volume in a single day can exceed 10 million, which is evident in its popularity.

3. "My research is not for the rich, but for all people to live longer"

In addition, Professor Kennedy said frankly, there is another important consideration for the reason why natural factors such as AKG and β-nicotinamide are respected: price. "I don't want my research to be for the rich, I want to make everyone live longer."

As we all know, scientific research is inseparable from the blessing of money. When an important scientific research result is implemented, the investment behind it may be billions or even tens of billions, which is almost doomed to the expensive attribute of high-end technology.

Last year, Israeli scientists found that the physiological indicators of hyperbaric oxygen inhalation for 3 months were 25 years younger, and the civilian "hyperbaric oxygen chamber" born on this principle became popular, but its starting price of 400,000 was daunting; the former world's richest man Bezos invested "Cell reprogramming technology" has already spent 3 billion US dollars at the beginning, and it is expected to produce millions in the future... There are many anti-aging technologies, but ordinary people can't afford to use them much.

With the help of bio-enzyme technology independently developed by scientists at the Chinese University of Hong Kong, the price of "Ruohui" tonic has dropped by more than 95%, falling into the thousand-yuan category. Perhaps this is another reason why it is welcomed by the Chinese.

As Professor Kennedy said: Biotechnology is developed to help all human beings. If the price is the threshold, then the birth of this technology loses most of its meaning.