University of California clinical study confirms: 8 times replacement of young blood, biological age nearly doubles
The human pursuit of longevity is a desire etched in its DNA.
According to legend, at the beginning of the 3rd century AD, there was a mysterious spring in the Aegean Sea, which could bring back the age of 18 when you drink it, which attracted Alexander the Great to lead a group of knights to find the "fountain of life". This story is also reflected in recent Western film and television works. In the movie "Pirates of the Caribbean", Captain Jack fought fiercely with pirates in order to compete for the "Fountain of Youth".
In the past, none of these legends were believed. Today, in the 21st century, modern science seems to have found the "fountain of life", which is not in a corner of the world, but exists in the human body. A few days ago, a number of studies have found that there is a mysterious power in the young blood that can make older individuals younger.
01 The mysterious veil of "The Fountain of Life" was unveiled, and the exchange transfusion therapy first appeared
In 2005, a research team from the University of California at Berkeley published a paper in Nature announcing that the replacement of young blood could make older individuals younger, arousing heated discussions in the academic community.
In the experiment, the researchers surgically cut young and old mice from the side of their abdomens and sutured their blood vessels together. Since the mice are close relatives and injected with anti-rejection drugs in advance, the two No rejection will occur.
After 5 weeks of blood exchange, the old mice showed amazing changes: the hair turned from white to black and shiny, the muscle strength increased by 30%, and the indicators of liver, kidney and stem cells were improved in an all-round way. growth"; in contrast, the young mice were sluggish and unresponsive, suggesting that their age was "averaged."
Once the study was published, more research on young blood began. In May 2020, a research team led by Professor Steve Horvath of the University of California announced that 8 injections of young blood were administered to 6 middle-aged mice. It is equivalent to 50 years old for a human being back to 25 years old.
After the blood exchange, the aging-related indicators of the middle-aged mice tended to be younger. The functions of the liver and heart were the same as those of the young mice, and even the cognitive function was improved. After a second measurement, both chronic inflammation and senescent cells in the middle-aged mice were significantly improved. In December 2021, "Aging" further refined the mechanism that "young blood can prolong lifespan", arguing that extracellular vesicles in blood carry the synthesis function of "longevity protein" and deliver it to all parts of the body. Aging weakens the properties of extracellular vesicles, reducing their ability to repair themselves.
02 Behind the Rich: Young Blood Supply Chain
The study of young blood has made foreign wealthy interested. According to "Fortune" report, Peter Thiel, founder of payment giant Paypal, spends $40,000 a quarter to trade fresh blood from 18-year-old young athletes, so he is known as the Silicon Valley "Vampires". This kind of transaction has even developed into an enterprise-level service. Companies headed by Ambrosia in the United States provide young blood to the rich at a price of $8,000. It is reported that there are currently more than 1,000 consumers registered.
The "Time School" from the science popularization team of Fudan University reported that three Russian biohackers (Alexander Fedintsev, Yuri Khait, Nikolay Sidorov) conducted a frantic self-experiment last year. They took half of the blood from the body and tried to dilute the aging blood. way to make yourself younger. Participant Yuri Khait said in an interview: "I had three surgeries (plasma dilution therapy) before and after, and the state after the operation was like drinking a few cups of coffee in the morning. I was very energetic, and this state would last for several days. like very much."
In view of the extreme behavior of the rich and bio-hackers, the "rambling" of exchange blood therapy has caused the US Food and Drug Administration (FDA) to issue an emergency statement, saying that "plasmapheresis" can only be used to treat patients with diseases. hidden danger. Warn those companies that have changed their blood to stop, otherwise they will be punished accordingly. Contrary to this serious accountability, many NAD and metformin supplements have passed FDA safety certification. After being reviewed by the FDA, the "Paweiluo pro" technology once became the favorite of the anti-aging market.
The University of Tokyo and Waseda University have carried out joint research on "Pavilo Pro" molecular agents. The study found that the key substances contained in such molecular agents can empower cells and improve the main signs of aging in mammals such as skeletal muscle, DNA, mitochondrial damage. The research team then recruited a group of volunteers with an average age of 50 years, and made them supplement the "Pavilopro" molecular agent for three consecutive months. After the experiment, the subjects showed different degrees of aging "reversal".
Various e-commerce platforms have aimed at the momentum and introduced "Pavilo pro" molecular agents into the domestic market. There are still many people who place orders at the four-digit price, and 90% of consumers are high-net-worth individuals with "free supplements". The JD.com platform alone has received 1w+ positive reviews. Most of the 35-55 year olds reported that their energy and sleep quality were improved after supplementing this type of molecular agent.
03 Exchange blood research is coming one after another, and it is no longer an extravagant hope for everyone to be a hundred years old
Compared with the NAD technology that has been endorsed by many experiments, the exchange transfusion therapy is slightly inferior, but because of its significant "rejuvenating" effect in mice, scientists are still conducting experiments on the therapy. The Chinese Academy of Sciences team found that young blood can enhance the ability of hematopoietic stem cells in elderly individuals; Professor Irina Conboy, the "founder" of exchange transfusion therapy, conducted human clinical experiments in August this year, proving that young blood can effectively improve subjects' immune function and chronic inflammation .
With the help of science, we can look forward to life after the age of 100. But when it comes to prolonging life, the immersion cost of trial and error for ordinary people is not much. Before the safety of exchange transfusion therapy is verified, it may be "let the bullet fly for a while". When the technology is mature and the price is no longer "for the rich", it is not too late to experience it.
The well-known investment bank Bank of America Merrill Lynch pointed out in the report that the future investment trend will be those industries dedicated to delaying human death. With the development of medical technology, the healthy life expectancy of human beings will soon exceed 100 years.