Everyone is expected to be a hundred years old? Israeli scientists: Hyperbaric oxygen inhalation for 180 days achieves physiological age regression by 20 years

You can be 20 years younger by lying down on oxygen.

This is not a fictional plot in a sci-fi movie, but the clinical research results of Israeli scientists.

In 2020, Prof. Shai Efrati of Tel Aviv University published a trial data showing that 30 elderly people over the age of 64 were cleared of senescent cells in the body after 3 months of hyperbaric oxygen inhalation 5 times a week for 30 minutes each time. 37% and 20% longer telomere length.

As one of the nine most recognized signs of aging in the field of biology, telomeres are the gold standard for measuring human life expectancy. A 20% extension is equivalent to 20 years younger! After this amazing result was published, the media rushed to report it, and the experimental results of almost sorcery also made Shai Efrati questioned from all walks of life.

In order to more comprehensively verify the conclusion, Professor Shai Efrati immediately launched a new clinical trial of hyperbaric oxygen chamber, and used the pathological "gold standard": "cutting human skin" to observe the youthful and miraculous effects of hyperbaric oxygen on the skin. The "knife cut human skin" refers to the removal of a 5x5 mm area of ​​skin behind the ears of volunteers through surgery, and the "reversal" effect on skin aging before and after hyperbaric oxygen treatment is observed by biopsy. The indicators include collagen/elastic fibers , capillaries, senescent cells, etc.

01 High pressure oxygen inhalation for 180 days, youthful state is visible to the naked eye

The research team recruited 13 elderly male volunteers with an average age of 68 years, all of whom have different degrees of "senile diseases", such as hypertension, hyperlipidemia, coronary heart disease and other basic diseases. And after 180 days of hyperbaric oxygen therapy. From a skin biopsy, several notable changes were observed:

Collagen fiber density increased by more than 10%

The length of the spandex is extended by about 30%

Increase the number of capillaries by about 40%

Senescent cells are reduced by about 20%

The above-mentioned changes in skin pathological indicators visible to the naked eye confirmed the effect of hyperbaric oxygen in "reversing aging". After the research results were published in the top journal "Aging" in the field of aging, it also saved a lot of reputation for Professor Shai Efrati.

Prof. Shai Efrati, who has always been skeptical, also said frankly about the limitations of the study: due to the operation involved in the experiment, there were not many volunteers who voluntarily participated, so it was impossible to set up a control group, and it was impossible to evaluate the reversal effect of hyperbaric oxygen on skin photoaging. . But all in all, this is the first time in the history of aging that the histological level of seeing is believing, adding strong evidence that hyperbaric oxygen therapy can significantly improve skin aging.

02 Hyperbaric oxygen chamber, the "big toy" of the rich and famous

David Sinclair, a Harvard professor who is known as the "Godfather of Anti-aging", generously disclosed his exclusive secrets on Twitter after seeing the hyperbaric oxygen clinical trial, which he made public as the "platform" of the hyperbaric oxygen chamber. Also on the list is NAD technology.

The doubts of the academic community are left to scientists for academic refutation, while the doubts of ordinary people are mostly due to the fact that the new method of hyperbaric oxygen chamber has not been popularized. In fact, the hyperbaric oxygen chamber has been put into use for hundreds of years, and it is not difficult to see it in tertiary hospitals and medical institutions.

It seems that in the anti-aging circle, the use of hyperbaric oxygen is nothing new. The oxygen chamber equipment used in Prof. Shai Efrati's experiment is priced at 4 million yuan, and the medical hyperbaric oxygen chamber needs to be "the right medicine", that is, "sick" can only be used, which also greatly limits the experience that ordinary people want to experience. Heart.

With the scientists conducting a number of experiments on hyperbaric oxygen therapy, civilian oxygen chambers have gradually been put into production and entered the market. It is reported that the high-speed rail manufacturer Qingdao Weiao has launched the intelligent hyperbaric oxygen equipment "O2ark", which makes the black technology of hyperbaric oxygen chamber "one step closer" to ordinary people. Compared with the medical oxygen cabin, although the price is only one-tenth of the price, the price of 40w is equivalent to the down payment for a suite in an ordinary city, which still makes many people "deterrible".

Subject to the high cost of oxygen chambers, this big toy is still far from being enjoyed by everyone. Anti-aging around the level of NAD in the human body has undoubtedly become the mainstream means of anti-aging after a number of scientific experiments.

Compared with the "rich man's toy" oxygen cabin, the "Aimuyin" NAD technology is more "approachable". According to media reports, this type of molecular technology was originally developed by a clinical trial conducted by Harvard genetics professor David Sinclair in 2013. The study pointed out that supplementing this type of molecular agent can increase the level of NAD in the body and reduce mammalian animals. Mitochondrial function is restored to a youthful state and life expectancy is extended by 30%, which is equivalent to 30 years of human life expectancy.

After the Aimine technology was put into production, it entered e-commerce platforms such as JD.com, and the four-digit price has never persuaded its consumers. This also reflects the great value of the domestic anti-aging market. Compared with the oxygen chamber equipment that costs hundreds of thousands, perhaps this is the "threshold price" that ordinary people want to anti-aging.

03 Anti-aging for everyone, or become a new trend of the times

In foreign countries, "wanting to become younger" has long been a trend. Singer Justin Bieber and his wife are one of the "old players" of hyperbaric oxygen + NAD technology.

Bieber chose to go to a private clinic every week for NAD injections because of the poisonous substances left in his body when he was young. According to his self-reported in the documentary, "It made me feel better and my depression has eased."

Bieber's wife Hailey was invited to the recording of the Kardashian family reality show in May this year. In the program, the picture of a group of people lying on the sofa receiving NAD infusion is very eye-catching, which also makes NAD technology popular again.

In addition to oral administration and injection, foreign markets have developed NAD supplementation methods such as sprays and patches. Admittedly, convenient sprays and patches are far less bioavailable than orals, and their safety and efficacy have not been clinically proven. However, this "NAD fever" still attracted the attention of Chinese scientists, and clinical experiments were carried out on Amylin-type anti-aging molecular agents.

Experiments by the Chinese Academy of Sciences, Tongji University and many other universities have confirmed that Amycin technology can effectively repair DNA damage and maintain telomere activity in the human body. What's more, studies have found that it can significantly improve several signs of aging in the human body such as hair loss, bone degeneration and muscle endurance.

With the endorsement of a number of scientific experiments, the Aimine technology has also "topped the list" in many e-commerce promotions. The JD.com platform alone has received nearly 9,000 positive feedbacks, most of which lie in improving sleep quality and hair loss. troubled.

In the future, more people will join the anti-aging team. The research and development of anti-aging methods such as oxygen chambers and NAD technology undoubtedly heralds great potential to prolong the life cycle of human beings.

With the invention of these emerging technologies, China will enter the age of longevity from an aging society, and we will eventually witness more historic scientific progress.