Is a blessing or a curse? American scientist human experiment: dilute half of blood, 69-year-old man returns to youth

From the medieval Hungarian countess Bartoli who killed 600 young girls and drained their blood for bathing, hoping to maintain their youth forever, to some people in ancient China beheading their heads just to snatch fresh blood, as a cure for a certain disease Medicine cited. In Eastern and Western cultures, people agree that blood has some kind of "extraordinary" power.

With the development of modern technology and continuous research by scientists, the mystery of blood has been gradually revealed. It is indeed related to the mystery of youth and longevity.

In 2005, Stanford University's Conboy team published an article in "Nature" stating that they have confirmed through "xenogeneic symbiosis" experiments that injecting young blood into old organisms can reverse aging.

The experiment selected 40 mice with the same blood type (to prevent rejection), half of them were 2 months old and the other half were 20 months old, and they were paired with young and old. Subsequently, the flanks of the two mice were surgically incised, and their blood vessels were sutured together to connect the blood circulation of the two to achieve blood exchange.

The results are amazing. During the 5-week experiment, the state of the two mice changed visibly to the naked eye. The hair of 20-month-old mice is getting darker and thicker, and many physiological indicators such as muscle, stem cells and liver tend to be younger. In contrast, the 2-month-old young mice showed obvious signs of premature aging, with sluggish movements and dull hair, as if all their vitality was "sucked" away by the old mice.

Once the research was published, it sparked a heated discussion in the academic community, and the infusion of young blood established a scientific connection with "return to youth". So much so that although the mechanism for blood to help "return to youth" was not clear at that time, the technology was targeted by a biotechnology company and copied to humans- the company launched "exchange blood with young people" at a price of $8,000. project . With the gimmick of this experiment, it attracted many experiencers. According to reports, more than 1,000 people signed up at the time, many of them well-known and rich.

However, due to the inability to guarantee the safety of the technology in humans, as well as the pressure from ethical and moral aspects, the project was later urgently stopped by the US FDA. Subsequent blood studies were also limited to animals. However, a recent study from the University of California has filled the gap in human clinical practice.

On August 24, the Conboy couple, the founders of the "exchange group," wrote in "Geroscience" that they do not need to exchange blood with "alien symbiosis", but only need to "dilute" half of the human blood to effectively reverse many markers of aging and improve immunity. Function.

The Conboys recruited 6 elderly (average age 69.3 years) and 2 middle-aged (average age 49 years) as volunteers, and administered TPE to these 8 subjects every other month with an albumin saline solution. (plasma dilution), record blood marker data.

After comprehensively comparing the experimental data for half a year, the researchers found that the cellular aging marker p16, the DNA damage marker 8-OHdG and many other indicators closely related to aging in the 6 elderly people showed a younger trend, which is similar to the younger 20 years old. of middle-aged people. At the same time, the number of major immune cells such as T cells and B cells increased significantly, which means that the immune system tends to be younger.

Legend: After TPE treatment, the proteome characteristics of the elderly population tend to be younger

According to the results of this study, the "exchange blood" program that was once suspended by the FDA seems to be able to make a comeback? Unfortunately, the researchers said that the current "plasma dilution technology" still has many risks, which may cause complications such as viral infection and allergic reactions, and cannot be extended to ordinary people. Further research is needed to ensure safety.

However, when the current anti-aging technology is at an explosive node, there is already a safer way to achieve rejuvenation from cells. In 2013, Harvard professor Sinclair discovered that the key anti-aging technology with high-luxury molecule celle-rator (the core substance of Japan's "Celere") can enhance immunity by activating cellular energy and prolong healthy survival. In subsequent clinical experiments conducted by the University of Washington and the University of Tokyo, the molecule also showed positive effects on the human body and was regarded as "oral stem cells".

After passing the safety verification by the US FDA, Japan, which has a serious aging population, quickly transformed it into implementation, and the mature achievement "Selori" entered the national Ginza such as Isetan and Daimaru, and all the way to China through cross-border channels such as JD.com , harvested a lot of high net worth people. According to the data, 75% of the sales volume of "Selerui" are middle-aged men between the ages of 36 and 55. At present, more than 5,000 comments have been accumulated, and most of them focus on "energy" and "improvement of immunity". It is regarded as a "Youth Recharge Card".

According to the analysis of CITIC Securities, this substance can reach a market size of 100 billion yuan in China in the long run. In contrast, the research on "exchange" is still quite immature, and there is still a long way to go to reach the perspective of mature technology such as the above-mentioned "Selery".

In addition, aside from the safety of the technology, there are more other controversies about the existence of the "exchange" experiment. Citing the "Time School" science popularization of Fudan's scientific research team, although "human exchange blood" has been banned by the FDA, there are still super rich people who operate through multiple channels. The most famous is Peter Thiel, the founder of Paypal and a Silicon Valley billionaire, who spends $40,000 a quarter in exchange for fresh blood from 18-year-olds. For this reason, he is also known as a "vampire" by outsiders.

As a result, many people expressed concern about this technology. Under the temptation of the huge potential benefits, it will endanger the lives of ordinary people, and it is not in line with traditional ethics. Of course, some people said that the development of science and technology should not be bound by traditional ethics.

But obviously, whether it is the US FDA's ban on "exchange blood", or the breakthrough of the Conboy scientist couple's experiments, they all show that the development of science and technology should have humanistic feelings, and some places are still restricted areas that cannot be touched. The breakthroughs in anti-aging technologies such as Celeron also prove that technologies developed within a safe range can still achieve the results people want. Scientific research should return to rationality.