The real version of 'rejuvenation'? American scientist gene therapy for 5 years, biological age regressed by 28.6 years
The ultimate human need is to live as long as possible.
From ancient China Qin Shi Huang sent Xu Fu to lead 3,000 boys and girls to go out to sea to search for immortals and medicines, to Western Alexander the Great who personally went over mountains and mountains to search for the legendary "Spring of Youth", Changsheng has never lacked crazy believers. In modern times, with the progress of life science and technology, people are keen on Those who are here usually become scientists with professional backgrounds, and even don't hesitate to conduct experiments as "novice mice". Dr. Brian, a 64-year-old biologist in the United States, is a typical example.
US scientists 5 years of "electric shock" experiment, biological age reduced by 28 years
Dr. Brian is known for his boldness and aggressiveness. In order to save as much time as possible, he has given two gene therapy injections for a total of 5 years. The specific operation is as follows: injecting plasmids containing hormones into the muscle, then electrifying the injection site, and promoting these plasmids into the cells through current stimulation. During this time, Brian also attempted two simultaneous senescent cell removals.
The research data shows that after the end of the entire course of treatment, Dr. Brian's biological age was 28.6 years younger than his actual age, and the epigenetic level was also "visually" reversed by 6 months, which is the golden sign of biological aging. The telomeres, converted into time, are equivalent to prolonging the survival period of 7 months. In short, the upper limit of lifespan does not appear to have been extended much, but the healthy lifespan has been significantly improved. The research was published in the renowned journal Rejuvenation Research.
In addition, Brian himself also revealed that two gene treatments improved his sleep quality and food intake respectively, and also miraculously healed the old injury on his knee, he said: "I was in a motorcycle accident when I was 18 years old. A dent and a 0.6 x 1 x 2.5 cm lump were left on the kneecap. But after 3 weeks of gene therapy, it disappeared completely."
When describing this passage, Brian's tone sounded very excited, clearly confident in his own research.
Confident or Crazy? Harvard professor experimented with whole family
People like Brian who believe in professional judgment and conduct experiments themselves are not rare in the American scientific community, and some scientists are even more crazy. Sinclair, a Harvard professor who is known as the "Godfather of Anti-aging", not only regarded himself as a novice mouse, but also took his whole family together, calling it a small-scale clinical experiment.
In 2013, Sinclair found in his experiments that the longevity protein sirtuins could be activated by exogenous supplementation of No. 1 coenzyme (the core substance of "Aimuyin"), and 18-month-old (equivalent to 60 years old in humans) old-aged experimental mice continued to ingest it. One week after the molecule, the remaining lifespan was extended by nearly 30%, and multiple aging indicators (muscle/hair/bone) were significantly reversed. The research was published in the renowned journal Cell.
Although it is only an animal experiment, Sinclair himself is convinced of this, and it is quite crazy to mobilize the whole family (except his younger brother) and even the two pet dogs in the family to take the molecule. You know, at the time, before a full-fledged supplement such as "Aimine" was available, Sinclair and his family were taking a laboratory-made powder. Fortunately, the results seemed to be quite positive.
Sinclair once said in an interview with Australia's "The Monthly" that after taking the methylation circadian clock, he was 20 years younger than his actual biological age after taking the molecule for a long time, and his self-evaluation was 20% more youthful. His father, who is in his 80s, is not far behind. Not only can he easily deadlift 115 pounds, but he can still easily win high physical activities such as rock climbing and rafting. Sinclair's younger brother also accused his brother in an interview of using him as a "control group". Younger he looks older than Sinclair.
After the release of relevant interviews, the name of Sinclair's "Anti-aging Godfather" spread like wildfire, and the market for dietary supplements such as "Aimuyin" was once promoted. According to JD.com’s backstage data, the supplement has reached more than one million people since it entered the online platform in 2018, and the single product repurchase rate is nearly 70%, making it a rare “phenomenal” product in the industry. The discoverer, Sinclair, has also become more and more famous, and was once selected as one of the "100 Most Influential People in the World".
3. The old science explosion node is here
Humanity is on the eve of an unprecedented increase in the quality and length of lifespan. In 1958, the slogan published on the cover of the American "Time" magazine was "Growing old usefully", and by 2015 the slogan gradually evolved into "This baby could live to be 142 years old. age)".
With the breakthrough of life-aging control technology, more and more "pioneers" like Brian and Sinclair are attacking themselves and want to be the first to become the first wave of long-lived new humans. Encouragingly, all of their attempts seem to be paying off.
The well-known writer Liu Cixin once wrote in "The Wandering Earth": "You are walking on the plain of life and encounter a wall head-on. The wall is infinitely high up, infinitely deep down, infinitely far to the left, and infinitely far to the right. Infinity. What is this wall? Death."
Today, humanity is charging against this wall. Maybe you and I have the opportunity to become witnesses to history.