Is it bad to eat too much? 'Nature' pointed out: night fasting can rewrite aging genes, or can prolong life by 18%

"Eat is a blessing", "people are iron rice and steel, and if you don't eat a meal, you will be hungry." In the traditional perception of the Chinese, eating well is the premise of doing other things well, on the contrary, if you are hungry, you will be hungry. It will damage your health, but a series of related studies that have appeared recently are telling us that eating less can actually live longer.

Professor Liu Ying from Peking University School of Biological Sciences used nematodes that have almost similar aging changes to humans as research objects. After artificially controlling the nematodes' food intake for a period of time, the researchers found that the eat-2 gene in the nematodes changed, mainly It is manifested that its survival time is significantly prolonged, or even doubled.

Coincidentally, another study published in the 100-year-old academic journal "Nature" also added a modern scientific basis for "eat less and live longer". Scholars from Columbia University in the United States put forward an idea, mainly around prolonging the night fasting time. To be carried out, the test results proved that the remaining lifespan of the organisms can be extended by about 18%.

The leader of the study, Dr. Mimi Shirasu-Hiza and his team, developed four implementation plans, namely, eating at will, eating from 6 to 18 o'clock every day, fasting the next day, and not eating after noon the next day (noon 12 o'clock to 8 o'clock the next day). The results show that, among all the schemes, only the fourth one, that is, skipping food after noon every other day, can prolong the average survival period of the female fruit flies participating in the experiment by 18%, and the male fruit flies Drosophila is 13 percent longer.

In addition, the researchers were surprised to find that the aging state of fruit flies has also been positively transformed, and some of its own aging diseases have also been alleviated to a certain extent, which means that they can not only live longer than other fruit flies , and more healthy. If night fasting is changed to daytime fasting, this effect of prolonging life will be relatively reduced. Therefore, perhaps "no food after noon" is the key to this method.

Why emphasize this "nighttime" state? Industry insiders explained: Because at night, if the human body is hungry, the body will spontaneously initiate a mode called "autophagy", which means that normal cells will phagocytose those damaged or old cells. , This situation can fundamentally delay the aging process of the human body.

Nevertheless, for most of us ordinary people, it is really a painful thing to resist the temptation of delicious food to taste buds when we are hungry, and considering that everyone's physical condition is different, their health The degree is different, so scientists also said that it is not recommended to voluntarily do not eat after noon, otherwise it may be counterproductive and have adverse consequences.

In this regard, Professor David of Harvard University Genetics provided a more feasible solution. He found in a mouse experiment that a human endogenous substance "WLife" with the main effect of revitalizing cell energy, mice in After regular intake of the substance for a period of time, mitochondria, telomeres, chromosomes, etc. in the body showed the same effect as young mice, and an additional gain of about 1/3 of healthy survival.

Compared with "no food after noon", WLife can achieve a similar effect, and can save users from hunger, and because the level of technological development has entered a mature stage, domestic biotechnology companies such as LightWeijian have achieved mass production. The iterative results of the same name of WLife have been pushed to popular platforms such as Kaidong and Tianzhu. We used to think that human intervention in aging was out of reach, but now the development of science and technology allows ordinary people to easily feel the benefits of the progress of the times .

In the past 100 years, with the boost of modern medical care and technology, the average life span of human beings has increased from 34.7 years to 74.3 years, showing a doubled increase. Although we cannot avoid birth, aging, sickness and aging, we can find the key to solving the problem. , you can gradually overcome it.

Ten years ago, Google founder Larry Page publicly stated that compared with the Internet, life science and technology created by human beings can better help build a better world, so he took out 700 million to set up Calico Biotechnology Enterprise, officially to The laws of nature have declared war; while social networking giant Zuckerberg has invested 600 million in related biological research and is committed to making a "general map" of human cells; the former world's richest man, Beibei, who has always had a great interest in this way Soth, who directly dumped 20 billion, mainly studies gene reprogramming technology, and has already achieved certain results.

At the same time, Professor Liu Guanghui of the Chinese Academy of Sciences and his team also reported "good news". After retrieving more than 20,000 sets of human genetic data, they finally found a kind of human aging "switch", that is, the KAT7 gene. Knocking out this gene from the body extended the survival of mice by about a quarter.

Scientists from the Massachusetts Institute of Technology pointed out that in the next ten years, centenarians may become common.