Extend life by 29%! Scientists find the 'switch' for cells to return to youth, opening the century-old era?

Humans have never stopped chasing longevity.

Ancient kings cultivated their bodies through alchemy, eager to penetrate the secrets of heaven; modern rich people use technology to recharge their lifespan. For example, Silicon Valley billionaire Peter Thiel spends $40,000 a quarter to replace the plasma of young people around the age of 16 in order to live to the age of 120. Hong Kong gambling king Stanley Ho takes "860,000 injections a day" for brain-boosting injections for 11 years.

The rich are very fond of "extending life", and they don't hesitate to invest heavily in life science and technology to make the sci-fi plot of extending life a reality. Recently, the University of Porto published a paper in the top journal "Nature Aging", which proved the feasibility of reversing aging from a new perspective, and successfully extended the lifespan of cells by 29%, triggering a great response from the regenerative medicine community.

This research comes from the team of Elsa Logarinho of the University of Porto in Portugal. In the experiments, the researchers discovered a novel transcription factor, FOXM1, that controls the ability of cells to proliferate and prolongs the lifespan of animals.

In aging research, the loss of cell proliferative capacity is considered to be a prominent feature of cellular aging. Restoring the ability of cells to proliferate is expected to achieve a certain degree of "rejuvenation".

In order to confirm the positive effect of FOXM1 factor on cell proliferation, the researchers took natural aging mice as experimental subjects, and increased the expression of transcription factor FOXM1 in vivo according to the strategy of "give for 3 days, stop for 4 days". Survival curves and body weight changes were continuously recorded throughout the procedure.

The experimental results exceeded expectations. A number of aging indicators in the mice were significantly reversed, including the alleviation of age-related muscle fiber atrophy, the improvement of the homeostasis of the already aged dorsal skin tissue, and the significant increase in subcutaneous fat, which also slowed down the aging-related weight loss, etc.

What is even more exciting is that the scientists also found that after removing FOXM1 overexpression for 5 days, the improvement effect on cell senescence phenotype of the previous 4 days of overexpression was still better, compared with the original senescent cells without treatment. Significant difference. After cessation of overexpression for 5 days, re-administration of activated FOXM1 expression was able to further prevent the re-accumulation of the senescent phenotype.

This has once again confirmed the feasibility of delaying aging by interfering with cells. Before that, Bezos, the world's richest man, invested 20 billion in "cell programming technology", and established the world's most expensive aging research institution Altos Labs with the University of Cambridge. With the participation of the world's top scientists including Nobel Prize winners, the research results were published in the top journal "Aging Cell", which attracted extensive attention from the relevant academic circles.

This scientific research result shows that after the scientists carried out the "somatic cell reprogramming technology" on the old experimental mice for a week, the body of the old mice has undergone significant rejuvenation changes. It has returned to its youthful state, and at the same time, the ability to repair genes weakened by aging has also been greatly improved. The different degrees of improvement in multiple aging markers reconfirmed the reversibility of cellular aging.

Most notably, Japan's "Celorui Technology", which also focuses on delaying cell aging, is also the first to truly implement technology, from Ginza, Japan, to China.

According to the data of the "Time School" of the domestic Fudan science team, "Selori Technology" was developed by Japan's Yuansheng Biological Industry Co., Ltd. In April 2021, Japan's Professor Shinichiro Imai and Professor Sinclair, the "Godfather of Aging", joined forces to conduct human experiments on such technologies.

Taking 25 middle-aged and elderly women aged 55-75 as experimental subjects, the experimental process lasted for 10 days. The results showed that the regeneration and recovery ability of their tissue cells were enhanced. And no adverse reactions occurred. This scientific research achievement has also been included in the world's top journal "Science". In recent years, China's Tsinghua University, Peking University, Guangzhou Sports University and other universities have also joined its research ranks.

In March 2020, the Japanese Ministry of Health, Labour and Welfare officially included it in the list of non-medical products. Now such substances have entered domestic platforms such as JD.com. As one of the few successful interventional cell aging technologies, the complexity of its technology makes it simple The price of the bottle is as high as 10,000 yuan, and it is called the "ceiling" of the anti-aging industry by netizens, so there are many disputes.

However, it seems that the wealthy who are eager to delay aging as soon as possible are not affected by it. According to JD.com data, Cellerui Technology is showing a fission-like upward trend year by year. Among the more than 20,000 feedbacks, the positive feedback exceeds 97%. For the Chinese who have a tradition of self-cultivation, life extension is of course serious.

Whether it is the novel transcription factor FOXM1 discovered by Portuguese scientists or the Celeron technology developed in Japan, it will increase the chances of humans getting longer lifespans. According to statistics from the University of California, Berkeley and the Max Planck Institute, it is concluded that in the United Kingdom, children born in 2007 have a half probability of living to the age of 103, while Japanese children have a half probability of living to the age of 107. , which can vaguely see traces of life science and technology means.

There is a view in "A Brief History of the Future" that as plagues, famines and wars that have long threatened mankind have been conquered one after another, mankind will face new to-do issues: immortality, happiness and becoming an upgraded human with "divine nature". In the future, the age of 100 may really become a reality.