'Irregularity factor' found in deer antler? Peking University and Chinese Academy of Sciences jointly confirmed that 14 aging indicators have reversed

60 days to reverse 14 key indicators of aging? This is not science fiction, but a new development in aging medicine in China.

Not long ago, the scientific team of the Chinese Academy of Sciences, Peking University and other research institutions released an experimental result. They locked a small molecule found in deer antler and successfully reversed 14 aging indicators of the body. The relevant results were published in "Cell Discovery" under the top international journal "Nature" has aroused great repercussions in the field of aging medicine.

01. Aging Pause? 14 aging indicators reversed

Scientists selected salamanders and deer antlers and compared them with the tissue cells of primates such as humans and monkeys to find the reasons for the huge differences in the ability of "rebirth" between different species.

Through a large amount of sequencing data, the research team finally pinpointed a substance called "uridine". The small-molecule metabolite of "uridine" is very high in regenerative animal tissues. After the researchers supplemented the stem cells of the aging population with uridine substances, the mitochondrial activity of the related cells was significantly improved, and correspondingly, the cell regeneration ability and genome stability were improved.

In animal experiments, 22-month-old mice (equivalent to 75 years old in humans) were continuously supplemented with uridine for 60 days. It was found that up to 14 important aging indicators were significantly improved in mice. The aging degree of muscle cells, cardiac function and The liver damage was improved, and the hair and damaged cartilage were regenerated to a certain extent.

02. The underlying mechanism: improving the mitochondrial energy supply of cells

The star substance "uridine" that was "discovered" in this study is actually an endogenous substance that exists in the human body, and also widely exists in breast milk, vegetables, grains, internal organs, and fish. The content is very small.

This shares an underlying mechanism with the "coenzyme I" substances that are prevalent in the medical field of aging. Previously, the Harvard geneticist D. Sinclair's team found that the intake of human endogenous substance coenzyme I (the core substance of the currently popular technical achievement "Panovit") can significantly improve the quality of cell mitochondria, thereby prolonging the time of 18 months (equivalent to 60 years in humans) for 31% of the lifespan of mice.

Coenzyme I substances became famous for a while and became a research hotspot in the field of aging medicine. In just a few years, hundreds of related papers have been published in top academic journals such as "Nature" and "Science".

In China, the United States, and Japan, the results of human clinical trials were published simultaneously. A 65-year-old man orally taking 250 mg a day improved muscle performance such as muscle, grip strength, and pace by about 7%. A century-old Japanese pharmaceutical company immediately launched the technical achievement of this substance, "Palowe", in response to the growing aging trend in the country.

Similar to coenzyme I substances, the uridine molecule discovered by Chinese scientists this time also acts on the mitochondrial tissues of cells closely related to aging, which can significantly reverse the aging indicators of cells and improve the heart, heart and health in a short period of time. The aging indicators of important organs such as muscles have great market potential to become the next generation of "reversing aging molecules".

03. With the outbreak of multi-national aging intervention technologies, can healthy aging be achieved?

In recent years, the global aging trend has greatly promoted the advancement of aging technology-related industries. As of the end of 2021, the United States has invested as much as $256 billion in this field, followed by China with $31 billion. Japan, which has entered the era of super-aging, pays more attention to investment in this field.

"Reversing aging is not a science fiction, but a goal that can be achieved through the advancement of life sciences," said Yoichi Nabeshima, Kyoto University School of Medicine. Immediately, CRDS, the think tank of the Japan Science and Technology Promotion Agency, officially included the clinical research of "Panovit" substances into the national budget, and planned to build Japan into a model "longevity power" in the world.

Like the enthusiasm of the top leaders in academia to publish papers, the market competition around aging control technology has also started early. Before the research and development of "Panovit" substances became popular, professors David Sinclair and Shin-Ichiro Imai, who worked in two world-class universities, Harvard and Washington, respectively, began to use coenzyme I experimental reagents privately. It is a loyal fan of its precursor substances. After "the experience of testing the water in person is very good", Li Chaoren, the former richest man in China, predicted that the market prospect of this technology is huge, so he invested 200 million Hong Kong dollars for this, and took the lead in establishing a territory in the field of biotechnology.

Since its introduction into China by JD.com, “Palowe” and other achievements have been released several times as sold out announcements, and once won the top spot in the sub-category market, quickly harvesting the minds of a group of domestic median-income groups. Regardless of whether it is a placebo effect or not, the theories such as "enhanced energy and better sleep" exude a seductive charm in the current fast-paced social atmosphere. It also makes this type of aging control supplements tend to spread to the 35-year-old middle-aged group.

Capital investment and technological breakthroughs from many countries have become the basic driving force for building an industrial map. This is also an important reason for the attention of the uridine research of the Chinese Academy of Sciences: Will the new "young molecules" bring new application prospects? With the emergence of technological achievements in many countries, can we break the monopoly, break through the barriers of high prices, and make life extension technology available to ordinary people? In the next 3-10 years, with the implementation of various research results such as uridine molecules, we may have more choices.