'kidney damage' in patients with nephrotic syndrome
Most patients with nephrotic syndrome need to use: the most classic, most economical, most effective, and most effective measures to deal with "negative effects" of glucocorticoids (hereinafter referred to as hormones); if it is a primary lesion and there are no contraindications, the first choice Drugs are naturally hormones; however, many patients are always concerned about the side effects of hormones, and do not accept this treatment for a long time; do you know that it is these delays that will greatly affect the condition; there is this phenomenon in clinical practice, that is, those It is finally confirmed that for patients who can achieve remission with hormone therapy, the time of remission is closely related to the time when they enter hormone therapy: patients who enter regular hormone therapy more than one month after the onset of disease often can achieve remission within one month. Those who started regular hormone therapy 3 months after the onset_needed treatment for 100 days to get relief, while those who entered the hormone therapy program 6 months after the onset_resulted in remission after one year of treatment, and those who started hormone therapy in August after the onset, Then the disease that should be relieved (such as those with mild lesions) is difficult to relieve! This situation all shows that: nephrotic syndrome itself has the act of "damaging the kidney" and aggravating the disease; delaying treatment, especially delaying hormone treatment, will drag the disease into an intractable and uncomfortable "mire"; Such an elderly male patient with nephrotic syndrome was "lucky" and expected to take "bed rest" to relieve his condition, but the delay was only seven days. Needless to say, the infusion of albumin will cost more; why just a small delay in the application of hormones will cause such a "repercussion" of the condition; how does nephrotic syndrome "injure the kidney" What about? But let us analyze them one by one:
The "kidney injury point" of patients with nephrotic syndrome...
The large amount of proteinuria produced by nephrotic syndrome will directly damage the renal tubules; this is because these large amounts of proteinuria leak out of the glomeruli and enter the renal tubules, and the renal tubules will receive the signal from the body: "rescue" , Recycle these "subtle" substances_proteins; thus, renal tubular cells will rush to "rescue" these proteins "ashore", they "recycle" by "phagocytosis" these proteins into the body; these proteins are too much, Some types of protein also cause damage to the renal tubular epithelium, "phagocytosis" too much protein, causing the normal structure of the renal tubular epithelial cells to be "squeezed" and injured, resulting in aggravated renal tubular damage, which is called nephrotic syndrome Caused by_the first "injury to the kidney";
Severe edema in nephrotic syndrome is one of its characteristics; and edema not only occurs in the limbs, but also in the abdomen and gastrointestinal mucosa, which will cause digestive and absorption dysfunction, natural metabolic disorders, increased acidic metabolites in the body, and " "Acidity" increases, and the "acidity injury" of the blood meridian and kidney naturally increases. It is the basic guarantee for the continuation of the treatment of the disease; otherwise, if the patient cannot even guarantee the basic nutritional intake, how can he treat the disease? Therefore, this is also the "benefit" of early application of hormones, that is, after the rapid suppression of kidney lesions, less protein will be lost, edema will not be so severe, gastrointestinal function will not be "affected" much, and you will be able to Ensure the basic nutritional needs for survival and ensure the smooth progress of treatment;
Patients with nephrotic syndrome have decreased immune function. This is an indisputable fact; the continuous loss of protein in the urine is like a wound "bleeding" non-stop. How strong is the body's resistance? Therefore, it is "common" to have repeated infections, and the double "high pressure" injury (hyperglycemia, hypertension) of sympathetic nerve excitation caused by these infections, the release of toxins from pathogens, and the deposition of complexes between pathogens and antibodies in the kidneys "Blood bruises" caused by injuries, pathogens and toxins will undoubtedly make kidney damage more serious, which is caused by nephrotic syndrome_the third "kidney damage".
The above are only the "kidney damage" of nephrotic syndrome that we can see and touch; there are many tiny invisible lesions: such as platelet aggregation, prothrombin activation, fibrinogen deposition, release of inflammatory mediators, Renal intrinsic cells (epithelial, endothelial, mesangial cells) are involved in the "snowball" effect of disease amplification, and hyperlipidemia directly damages the kidney, which continuously leads to the aggravation of renal damage; thus, the delay in application is the most powerful The hormones that inhibit kidney disease are undoubtedly giving up the "strongest main force", and the disease's "breaking the embankment" is unstoppable; therefore, patients with nephrotic syndrome who are still wandering should accept hormone therapy decisively, the sooner The better the effect of treatment, the more appropriate calcium supplement measures, anticoagulant measures, diet therapy, the application of traditional Chinese medicine and Chinese patent medicine for treating kidney and preventing hormone side effects, most patients will strive for better results, and can also avoid Hormone side effects, the chance of relapse after remission will also be reduced, such a "kidney benefit, why not do it?"