National Health Commission approves three clinical trials of stem cell therapy for spinal cord injury
In recent years, with the continuous development of stem cell and regenerative medicine technology, the research of stem cell therapy to repair spinal cord injury has entered the clinical trial stage. Recently, the National Health Commission approved three clinical research projects on stem cell therapy for spinal cord injury:
Multicenter clinical study of hUC-MCSs in the treatment of subacute spinal cord injury
Multicenter clinical study of hUC-MCSs in the treatment of early and chronic spinal cord injury
A multicenter clinical study of hUC-MCSs in the treatment of late chronic spinal cord injury
Spinal cord injury has been a worldwide medical problem for many years and is a serious complication of spinal cord injury. It has attracted the attention and attention of clinical researchers, and the number of related clinical studies is increasing. carried out in many countries. The latest results published in the journal "Science China" announced that there are 42 related clinical studies registered in the Clinical Trial.
Spinal cord injury is a fracture of the vertebrae or cumulative spinal ganglion injury caused by external force. The injury of multiple neuronal and glial cell subtypes together leads to axonal severing, demyelination and scar tissue formation, resulting in severe dysfunction.
Therefore, to repair spinal cord injury and restore original neural function, regeneration of multiple axonal projections is required to rebuild lost neuronal diversity. However, in the actual process of human self-repair, the spinal cord lacks this supportive environment, which hinders nerve repair and regeneration after injury, and the clinical prognosis is poor.
Through the multi-directional differentiation and regeneration potential of stem cells, the damaged spinal cord can be repaired and reconstructed. At present, clinical trials have demonstrated the feasibility of stem cell transplantation. Zhang et al. performed stem cell transplantation on 50 subjects with acute spinal cord injury, and took 50 subjects with the same course of disease as the control group to observe the recovery of functional indicators in the two groups at 3, 6, and 12 months: improvement rate in the study group It showed an increasing trend, and the improvement effect was significantly higher than that of the control group.
The results of the study showed that mesenchymal stem cells can significantly promote the recovery of neurological function in subjects with spinal cord injury.
Shroff G's research team used a combination of stem cell therapy and physical therapy to treat 226 subjects with chronic spinal cord injury (153, 32, 36, and 5 grades A, B, C, and D; 136 were paraplegic, 90 Cases of quadriplegia) were observed and studied, and the results of the intervention were significant:
15.0% were upgraded from A-level to B-level, and 37.3% were upgraded from A-level to C-level;
40.6% are upgraded from B to C, and 3.1% are upgraded from B to D;
13.9% from C grade to D grade, and 60.0% from D grade to E grade.
In fact, the repair of spinal cord injury is a complex and slow process, involving not only spinal cord nerve damage, but also damage to multiple systems, such as muscle degeneration, peripheral nerves, and psychological disorders. The results of this study show that the use of stem cell therapy to complement other traditional therapies can promote overall functional improvement in patients with spinal cord injury, so the establishment of a comprehensive program of clinical intervention, rehabilitation, and psychological counseling is necessary for spinal cord injury.
In January this year, an American biotechnology company announced that a clinical trial of stem cell transplantation in 22 spinal cord injury patients had achieved positive results, improving motor function; in February, Japan approved the world's first induced pluripotent stem cell intervention for spinal cord injury In June, the first hospital in Taiwan to approve cell therapy has submitted a number of stem cell therapy technologies such as spinal cord injury to Taiwan's health authorities.
With the deepening of the understanding of the mechanism of nerve regeneration and the continuous development of regenerative medicine technology, the clinical research of stem cell therapy for spinal cord injury is transformed into clinical application, and the nerve regeneration of spinal cord injury and the recovery of motor and sensory functions are truly realized!
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