Extend life by 29%! Portuguese scientists turn on the 'switch' for new life extension
"Human's exploration of aging has never stopped". The former richest man, Bezos, offered a high salary of $1 million to attract scientists to explore the reversal of aging; the Saudi Arabian royal family announced that it would spend $1 billion a year to support research on "extending lifespan"... and recently published in "Nature Aging" A study was published, which confirmed the feasibility of inverse decline from a new perspective.
The team of Elsa Logarinho from the University of Porto in Portugal confirmed that the transcription factor FOXM1 has a potential molecular mechanism of reverse aging. In naturally aging mice, increasing the expression of FOXM1 can significantly extend the median lifespan by 28% and the maximum lifespan by 29% .
1. Extend life by 28%, scientists turn on the new life extension switch
In the field of aging research, there is a view that the loss of "cell proliferation ability" is a prominent feature of cellular aging.
Cells in the human body will replenish senescent or dead cells in the body through differentiation and proliferation. However, when cells divide for a certain number of generations, exhaustion also occurs, so that the cell cycle enters an "irreversible" state of stagnation, that is, senescent cells. The study found that cellular aging secretes 103 different proteins, many of which are potentially related to aging-related chronic problems.
In this experiment, the researchers divided the mice into naturally aging mice and HGPS mice with progeria for study. FOXM1 was overexpressed in these two mice to observe whether this "switch" could be regulated. "Cell proliferation ability", and then whether it can produce a reverse aging effect in physiological aging.
The scientists used the researchers to use two groups of 8-week-old mice to overexpress FOXM1 according to the strategy of "give 3 days, stop 4 days" for a total of 80 weeks, and detect the changes in the phenotype and molecular level of aging tissues at 88 weeks. Survival curves and body weight changes were continuously recorded throughout the procedure.
Surprisingly, the treatment group significantly increased median lifespan (28% increase) and maximum lifespan (29% increase) compared to the control group, slowed aging-related weight loss, and reduced skin, muscle, fat, aorta, etc. Significant improvement in key aging tissue phenotypes.
2. Mitochondria regulate cell proliferation, which is a key anti-aging strategy
In order to crack the code of aging, scientists have come up with different ways. The research on regulating cell proliferation has already attracted attention. If you search for keywords on CNKI, you can get more than 500,000 results in Chinese and foreign languages.
The experiments of Portuguese scientists this time have confirmed the good performance of transcription factor FOXM1 in enhancing cell proliferation in mouse experiments, but from the scientific research point of view, it is a long process from animal experiments to human clinical practice. Therapeutic targets for aging may be decades away.
Starting from mitochondria, regulating cell proliferation has become a key anti-aging strategy for "relative maturation". Mitochondria are called "power factories" of cells. The mitochondrial matrix contains all the enzymes required for the tricarboxylic acid cycle. The main function is to provide a steady stream of "power" for the proliferation and differentiation of body cells. Mitochondrial aging will cause stem cells to function abnormally, resulting in the inability of tissues and organs to "maintain renewal", thereby affecting the lifespan of the entire organism. The mitochondria-targeted regulation of cell proliferation channels and maintenance of youthful state, represented by "Panovie", has gained a place in the market.
The scientific research published by Harvard Medical School in the top journal "cell" confirmed that in the experiment, the key ingredient Mitolive of "Panove" improved the mitochondrial homeostasis of aged mice, and various key aging indicators such as muscle level and body homeostasis were reversed. To the level of 20-year-old human beings, it is equivalent to prolonging the human lifespan by 2.3 times. Obviously, the regulation of cell proliferation by mitochondria is a more advantageous strategy through the components contained in Pelowe.
Prior to this, the oxygen chamber therapy that "competes on the same stage" with mitochondrial targeting has also achieved scientific research. However, due to price barriers, it is currently only popular in small circles. In 2020, Israeli scientists published a clinical trial in "Aging", after a group of elderly people were treated with hyperbaric oxygen for three consecutive months, they were able to significantly stop or even reverse the aging process. Paris star Neymar once revealed that when he injured his thigh muscles, in order to recover in time, he would receive "hyperbaric oxygen therapy" every other day. The average price of O2 ARK hyperbaric oxygen chambers on the market is also six figures. Expensive high-tech products have quietly set off a "oxygen inhalation trend" among celebrities and rich people. After consultation, their experience store reservations in Beijing and Shanghai have now been arranged. three months later. However, although the oxygen chamber is good, the price is unbearable.
At present, the regulation of mitochondrial intervention in aging is still dominated by a new class of technological products. Compared with the six-digit O2 ARK hyperbaric oxygen chamber, the price is also a clear stream. On the current sale of the platform, some single bottles are priced at around 800. Directly hitting the price pain point is also the key to opening up the market for mitochondrial decay-reversing substances. It is important to note that the mother of the richest man, Musk, used to be a platform for mitochondrial decay-reversing substances.
The centenary of the whole people may come, and human beings have to face the problem of "longevity"
At the 2019 World Artificial Intelligence Conference, Jack Ma once envisioned a century of human beings: we will enter an era where everyone can live to be 120 years old, and there will be many new problems. Although "longevity" is a new topic, it is closely related to each of us, and the discussion on the topic of health and longevity under the information hot list is still in full swing.
"Do you really feel happy when you grow old without dying?"
"If this research is successful, it can change the anti-aging function of human cells and keep human beings young. But the death cycle of human beings still exists." Most of the keywords in the topic are "pension", "population explosion", and "injustice of lifespan" ” and other social issues.
According to WHO statistics in 2021, the average life expectancy in China is over 77 years old. According to the results of the Portuguese experiment, it is estimated that if humans can achieve a 28% life extension, everyone can live to a hundred years old. Whether it is the FOXM1 transcription factor that has not yet landed, the O2 ARK hyperbaric oxygen chamber that has landed but is expensive, or the relatively mature patented ingredients relying on mitotive, it seems to indicate that longevity is becoming a reality.
Linda Gratton, a professor of economics at the London Business School, said in her book Centenary Life, "What we need to do now is not to worry about the reality of this technology, but to think about how to plan our centenary life.
From the perspective of scientific research, extending the lifespan of mice by 28% is still a very important breakthrough. There is hope for the whole people to be 100 years old. Perhaps Musk is still looking forward to immigrating to Mars in his lifetime.
References:
Ribeiro, R., et al., In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan. Nature Aging, 2022. 2(5): p. 397-411.
Macedo, J.C., et al., FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence. Nat Commun, 2018. 9(1): p. 2834.