Ginger wants fire? American scientists found anti-growth molecules in ginger, eliminating 50% of senescent cells in 2 days
The ancients have respected ginger for a long time. Su Shi said in "Dongpo Miscellaneous Notes": "I take ginger for 40 years, and my face is like a child's face"; Confucius said in "The Analects of Confucius": "If you don't remove ginger, you don't eat much", which means you should eat a little every meal.
"Eating three slices of ginger early is better than ginseng soup", the ancients have long recognized the many benefits of ginger. Entering modern society, scientists push ginger to the "altar": ginger contains mysterious substances that can make people return to youth.
In May 2022, the American Institute of Aging Technology (NIA) published a paper in the scientific journal "Plos One", announcing that two "young molecules", 6-shogaol and zingerenone A, were purified from ginger, which can be used in 2 Eliminate 50% of senescent cells within days . Senescent cells are the "source of pollution" in the human body, which can make surrounding healthy cells sick and accelerate the aging of healthy cells, so they are also called "zombie cells". If we can accurately identify and remove senescent cells at the first time, we can achieve a certain degree of "rejuvenation".
In 2020, MIT Technology Review named senescent cell removal as one of the "7 breakthrough technologies in regenerative medicine." Bezos, the world's richest man, invested 3 billion US dollars to establish the ALOS Medical Research Institute to "declare war" on senescent cells.
The traditional removal method uses the combination of D+Q (dasatinib and quercetin). Although the removal effect is excellent, there is an "indiscriminate attack" - while removing aging cells, healthy cells will also be affected.
In this experiment, the scientists set D+Q as the control group and found that after 48 hours, 40% of the aged cells were successfully removed, but unfortunately, the proliferation of healthy cells was significantly inhibited. The D+Q combination shows certain toxicity and is only suitable for unconventional use in emergency situations.
In the ginger test group, the scientists treated senescent cells with two ginger extracts separately for 48 hours. The results showed that 6-shogaol had a similar effect as D+Q, possessing a certain scavenging ability and at the same time damaging healthy cells; but the performance of shogaol A excited scientists: not only did it not affect healthy cells, but its scavenging ability was better than Traditional way, up to 50%. Since ginger is almost "everywhere", if it is successfully commercialized, it means that the aging process has been changed.
Whether ginger extract will become the next epoch-making anti-aging molecule, it may be difficult to give an answer now. Scientists say the next step is to conduct human clinical trials.
In fact, ginger extract is not the only answer to clearing senescent cells. PCC1 found in specific grapes by the Chinese Academy of Sciences and fisetin found in strawberries have shown excellent potential.
At the same time, NIA colleagues, scientists at Harvard Medical School, have taken a different approach, trying to find a way to solve the problem of cellular aging once and for all from the "cellular engine" mitochondria .
According to information from the Fudan Aging Research Team, Shishi Pai, mitochondria are the energy engine of cells, providing 95% of the energy for cell operation. However, with age, there are certain obstacles in the mitochondria, and the cells will enter an aging state. In theory, if you can activate mitochondria and increase the quality and quantity of mitochondria, you can reverse aging and bring the organism back to youth.
Figure: Mitochondrial dysfunction leads to 8 signs of aging
How to reverse mitochondrial function? Harvard scientists have found the answer in the magic of nature.
In November 2013, D. Sinclair, a professor at Harvard Medical School, published a paper in the top issue of "Cell", announcing the discovery of a mitotive (mitochondrial optimizer) from avocado, broccoli and other fruits and vegetables, showing the effect of activating mitochondria. After using the substance for 14 days in aged mice, which are equivalent to about 70 years old in humans, it was found that mitochondrial function in their muscles was significantly optimized, and the methylated telomere test showed a 2.3-fold regression in physiological age.
This astonishing discovery has amazed scientists from all over the world. Follow-up studies by Washington University, Keio University, the Royal Swedish Academy of Sciences and other institutions of higher learning have followed up, and the results have been published in Cell, Nature, and The Lancet.
The country that took the lead in implementing the motilive application was Japan, which has the most serious aging population. Under the rigid needs of the huge aging population, the Ministry of Health, Labour and Welfare included this technology in the 2018 food list as one of the national normalization strategies. The clinical trial jointly organized by the University of Tokyo and Noda Pharmaceutical further confirmed the longevity potential of this technology in the elderly population.
Boaozhen Co., Ltd., a veteran biotechnology company in Japan, also responded quickly. In 2018, the motilive product "Pilovi pro" molecular agent was launched. According to online public information, it quickly occupied local shopping malls such as Tokyo Ginza and Mitsukoshi Department Store. Kazuo Tangzawa, head of the Tokyo area of Mitsukoshi Department Store, said: The local penetration rate is over 75%, and the next step will be to increase the introduction.
Now, the spring breeze seems to be starting to blow in the country. According to the Jingdong International 618 racing list, Palowi Pro has quietly climbed to the ninth position. The user portrait pie chart shows that 90% of its audiences are high-net-worth individuals in first- and second-tier cities along the coast, and their age distribution is over 40 years old.
It is worth mentioning that in recent years, Chinese scientists have also made frequent efforts in this field, and there is a tendency to overtake in corners. In the molecular research of mitotive, the Chinese Academy of Sciences and Qingbei have also carried out clinical trials one after another, which have confirmed the good results. If it is implemented in the future, by virtue of its status as a world factory, Nissan Piloway may be replaced by domestic molecules in the future.
Biologist Juan Carlos once said: "As long as it is carefully controlled, it is indeed possible to reverse the aging process." The results of biological research that are increasingly blooming today are confirming the prediction. Qin Shihuang and Tang Taizong, who once fantasized about changing their fates against the sky, may also feel that they are "not born at the right time" if they see the results of modern life science.