The University of Tokyo's 'anti-aging' experiment was released, 250 mg per day, the elderly's muscle increased by 7% in 3 months

"Ageing doesn't have an effect on the body, but rather a faster pace, stronger grip, and more active muscles." This is not the plot of a novel, but the result of a study by Toshimasa Yamauchi, a professor of metabolic diseases at the University of Tokyo in Japan.

01. University of Tokyo clinical results: 3 months muscle performance increased by 7%

In 2021, the University of Tokyo, Japan, published an article in the "Nature" sub-issue announcing the discovery of "age-reversing molecules" that extended the life span of the elderly. The researchers recruited 20 male participants over the age of 65, arranged to take 250mg of "age-reversing molecules" every morning, and recorded data to observe physical changes. After 3 months, many physical indicators of the participants improved significantly. Among them, muscle performance such as pace and grip strength increased by about 7%, and the levels of pancreatic islets and testosterone of the elderly also improved.

It is reported that this experiment is the first of its kind in Asia, and was inspired by Shinichiro Imai, a professor of developmental biology at the University of Washington in the United States, who conducted research on the "reverse age molecule"-NAD precursor, which is different from previous experiments that targeted fruit flies, nematodes, etc. What’s more, this experiment directly involved human beings. Through a randomized, controlled, and double-blind placebo mechanism, the research team allowed elderly volunteers to take a certain dose of molecular precursors every day to help activate the vitality of mitochondria in the body and improve various physical indicators such as muscle strength.

In fact, as early as 8 years ago, the research on this molecule has caused heated discussions in the academic circles. In 2013, the Harvard University experimental team found that the mitochondrial stability and muscle strength of 22-month-old mice were comparable to those of 6 months ago by giving mice 7 days of intake of similar molecules. The extension to 4.6 months is equivalent to extending the human time from 6 years to 13.8 years. The release of the research quickly attracted the attention of China, the United States and Japan.

02. The total population has declined for 12 consecutive years, and the problem of aging needs to be solved urgently

As the world's largest aging country, Japan has always encouraged the technology of extending the health period to cope with social problems such as the continuous expansion of pension medical expenses and labor shortage. In March 2020, the Japanese Ministry of Health, Labour and Welfare listed the above-mentioned experimental molecular substances in the food list. Among them, Bioagen, a brand that focuses on activating mitochondrial life extension technology, has launched "Pylowe pro" anti-aging substances, and has continued to expand with many similar biotechnology companies and entered major supermarkets in Japan, which is considered to be a landmark inflection point in Japan's aging society.

According to the National Social Security Population Research Data, as of 2020, Japan's total population has declined for 12 consecutive years, from 128 million to 126 million. As of October 1, 2021, Japan's total population was 125.5 million, a decrease of 644,000 or 0.51% compared to October 2020. According to the most conservative estimates, the total population will decrease by 1/4 in 2065, and the aging situation can be described as shocking.

In addition, the data show that nearly 1/3 of the marriageable population do not consider childbearing. From this point of view, prolonging the survival period of the elderly is a helpless move for Japan to maintain the population base, and it is also the main reason for the rise of "Pavilow Pro" anti-aging substances.

In China, on the other hand, similar problems are imminent. Statistics show that during the "14th Five-Year Plan" period, the national elderly population will exceed 300 million and enter a moderately aging society. When the country's first generation of only-child parents enters middle and old age, there will be a wave of elderly care climax. In the continuous advancement of various elderly care service plans, major domestic platforms have launched a big health section, and related material products such as "Piloway Pro" have been actively introduced by Jing & East International as the representative to help the domestic aging population extend healthy lifespan.

03. The development of science and technology promotes another leap in life expectancy

The announcement of the anti-aging molecular experiment in Japan has not only caused positive responses from aging countries, but also prompted comparisons between the scientific community and other health technologies.

Liu Guanghui, Institute of Zoology, Chinese Academy of Sciences, found the "aging switch" KAT7, which can make 81% of mice older than 130 weeks (equivalent to 80 years in humans) through genetic programming; Israeli scientists believe that "hyperbaric oxygen chamber" can eliminate senescent cells in the human body , so that the domestic hyperbaric oxygen chamber "O2ARK" has emerged among high-net-worth individuals in first-tier cities; Bezos, the world's richest man, has invested in cell reprogramming technology to reverse the life cycle. Similar to Japan's "Piloway pro", these technical researches are all domestic A breakthrough in the shackles of life by surgeons.

In the past 100 years, medical technology, vaccines and public health have continued to improve. Human life expectancy has increased at a rate of 2.5 years per year. At present, human life expectancy has experienced two leaps. Technology has promoted the development of productivity, and the problem of famine has been initially solved. The use of antibiotics has decreased. unnatural mortality.

Now, facing the third leap in human lifespan, the lifespan will increase from 76 years old to 100 years old. In the middle of the 20th century, the British poet Dylan Thomas used a powerful brushstroke to announce the resistance of mankind to the fate of aging: "Don't go into that good night gently, old age should burn and roar at sunset!" The research team of the University of Tokyo, the Harvard science team, and the world's richest man, Bezos, are all the rebels of destiny in today's era, struggling to decipher the code of human aging. interest.