What's the matter with diabetics taking metformin and their blood sugar does not drop? It is important to understand
Metformin is a very common hypoglycemic drug at present, and it is widely used in clinical practice. Most doctors will require patients to take this drug, which makes many patients think that blood sugar will definitely drop after taking metformin. However, some people find that their blood sugar does not drop but rises after taking metformin, which makes them puzzled. In fact, the blood sugar of diabetics does not drop but rises after taking metformin, which may be related to the following reasons.
What are the reasons why people with diabetes do not take metformin to lower their blood sugar?
- Simply taking medicine without cooperating with other methods
Generally speaking, during the period when diabetics take drugs to control blood sugar, in addition to drugs, other aspects should also be paid attention to, such as life conditioning and diet. If there are still improper living habits and bad eating behaviors during taking the drug, such as frequent intake of high-calorie and high-sugar foods, it is easy to cause the blood sugar to not be absorbed and gradually rise. Taking the drug can only get a short-term hypoglycemic effect. Even after taking the drug, it will rise again due to the influence of food, causing the drug to have no effect. Or if you are sedentary for a long time while taking medicine, you do not insist on exercising. Exercise can improve insulin sensitivity, increase insulin secretion, and help control blood sugar. If you just take medicine and often sit for a long time without exercising, fat accumulation It can make insulin damage more serious, which in turn affects blood sugar.
- Unreasonable medication
In terms of mechanism of action, the hypoglycemic mechanism of metformin is mainly by inhibiting the output of hepatic glycogen, as well as inhibiting the intestinal absorption of glucose and promoting the breakdown of glucose in muscles, thereby helping to lower blood sugar in many ways. If the dose of the drug is reduced in order to prevent the side effects of the drug, the effect of the drug will be reduced. Or the interaction between various drugs, resulting in a decrease in the amount of metformin absorbed in the gut, which in turn affects blood sugar.
- Influence of intestinal flora
Drug resistance occurs when a drug is applied to different individuals. Drug resistance refers to the situation that some patients have unsatisfactory or complete failure when using drugs to treat diseases, and metformin is also one of them. Studies have found that there is a metabolite imidazole propionate in the gut, which is mutually exclusive with metformin, which means that the higher the concentration of this substance. The concentration of metformin absorbed by the intestine is reduced, resulting in a decrease in the effectiveness of metformin.
In general, the effects of various drugs in the body are different, and for metformin, if there is no obvious drug effect or other problems, most of them are related to the above reasons, understand clearly and correctly. Coping can maximize the effectiveness of metformin.