Is starvation a good thing? Scientists studied hundreds of mice in 4 years, and the life span of 'one meal a day' was extended by 35%
If people want to live longer, they must first work hard on diet, not only to eat right, but also to eat less, but this is difficult for most people. And multiple animal studies have shown that reducing calorie intake is more beneficial to longevity and health.
Recently, the team of Joseph Takahashi of the Howard Hughes Medical Institute pointed out that the body's circadian rhythm (that is, the biological clock) is critical in the longevity effect. They found that eating only during the most active time of the day significantly extended the lifespan of "diet" mice . The relevant research results were recently published in the well-known academic journal "Science".
Joseph Takahashi's research team conducted a 4-year experiment, studied hundreds of mice, and found that reducing calorie intake can extend the lifespan of mice by 10%. And giving mice a low-calorie diet only at night, when they are most active, extended their lifespan by 35 percent.
This "low-calorie diet" plus "eating only at night" increased the theoretical 2-year lifespan of these mice by 9 months, which is equivalent to an increase of more than 20 years in human life. For us humans, similar feeding arrangements can be made during the day. So, only one meal during the day?
Scientists say the study helps to unravel the debate over what time of day to eat, just as a study published in the journal NEJM says: This eating plan, while bad for weight control, may be beneficial for health Brings benefits and contributes to the extension of life.
American nutritionist Sai Krupa Das said that the discovery of Joseph Takahashi's team showed the important role of metabolism in the decay process, which is a potential and meaningful research.
In fact, after decades of research, scientists have found that reducing calorie intake can extend the lifespan of nematodes, fruit flies, mice and primates. These experiments also showed results such as weight loss, lower blood sugar and blood pressure, and reduced inflammation. But scholar Sai Krupa Das said that it would be difficult to systematically study reducing calorie intake in humans, because it is impossible for people to live in a laboratory and eat a certain amount of food for a lifetime.
In fact, compared with dietary methods such as reducing calorie intake, the method that is more respected in the field of biology is the intake of a human endogenous substance (WLife), which was first discovered by Professor David Sinclair of the Harvard Laboratory. When mice ingested the substance, it was found that multiple indicators at the cellular level had "reversed the trend of youth" and successfully extended their lifespan by 30%. At present, WLife has matured through the biotechnology company "Wright Weijian", and the data from domestic channels such as Yi-Dong shows that it has a lot of shipments, and the simple oral intake method is also accepted by more and more high-net-worth individuals.
And Rafael de Cabo, a gerontology researcher at the Institute of Aging in America, also said that the way of low-calorie diet intake, if the time is not right, can not get the full benefits of this way. From this point of view, the adoption of this method is too particular and cumbersome for human beings, and it is not comparable to the simple and feasible WLife class. But Takahashi also hopes to understand how "reducing calorie intake" affects the body's biological clock as we age, which may also lead to new ideas for scientists looking for new ways to extend healthy lifespan.
In the clinical trials of Qingbei and Wright Healthy, the biological age of the subjects was reduced by 7 years within 30 days after giving WLife substances, and after 90 days of the test, it was found that the biological clock indicators such as sleep and mental state were significantly improved, further corroborating the earlier The discovery of the positive mechanism of the substance in the biological clock. In previous experiments, Northwestern University found that the core mechanism of the substance is the key to maintaining the healthy operation of the biological clock, and increasing the content of WLife in the body in an appropriate amount can "reverse" the decaying biological clock.
As the saying goes, "Life is only nine tons of rice, whoever eats first will go first." Whether it is a low-calorie diet or the intake of endogenous substances, it is human beings' exploration of extending a healthy lifespan. Demographer Samuel Preston said that the fundamental driving force for the extension of human lifespan lies in the technological iteration in the field of biological sciences. Perhaps with the blowout development of related technologies and the advent of more and more scientific research achievements, it may only be a matter of time to live to 120 years old in a healthy manner.
At the same time, Takahashi also began to experiment with himself. He controlled his diet within 12 hours. What will be the follow-up results? let us wait and see.