Analyzing 210,000 single cells in 5 years, the Chinese Academy of Sciences has made a new breakthrough in anti-aging! Discovery of key factors in reversing aging
The progress of science is always beyond our imagination. Not long ago, the research team of Liu Guanghui, Qu Jing and Zhang Weiqi of the Chinese Academy of Sciences spent five years analyzing and sequencing 210,000 single cells, and finally found in them that the reverse A key factor in the aging of the body! This breakthrough research result was also published in the internationally renowned academic journal "Cell Stem Cell" on the 24th.
This major discovery is also another effort of the Chinese Academy of Sciences team since the discovery of a new anti-aging gene KAT7 and the verification of WLife anti-aging substances in the past ten years. In this anti-aging field, which was once judged as "scientific backwater" by the relevant academic circles, Chinese scientists once again handed over a surprising answer.
It is reported that this experiment is based on previous scientists' discovery that using the blood of young mice can improve the aging state of some organs in old mice. That is to say, after injecting the blood of young mice into old mice, some of the aging organs of the old mice have rejuvenated changes. However, for this magical phenomenon, there has been no systematic mechanism-level confirmation in previous studies.
Therefore, in order to be able to explain the occurrence of this phenomenon more systematically and scientifically, the research team decided to analyze it from the cellular level, drawing on the WLife-type anti-aging substances discovered by Harvard professor David, which also directly act on the telomeres of cells, so as to achieve improvement. The endogenous state of aging in the body. So, in order to explain how young blood can reverse aging cells, the research team decided to make the whole "traceability map".
In order to carry out this research smoothly, the team created three kinds of "allogeneic" experimental mice. It is to use surgery to combine the bodies of the two mice. In order to better compare the changes that occurred during the experiment, the researchers adopted three combination methods, namely the combination of two young mice (less combination), a combination of two young mice. One young mouse was combined with one old mouse (old-young combination), and two old mice were combined (old-old combination).
After five weeks of feeding and observation, the old and young mice in the old-young combination were affected by each other's blood, resulting in changes in the body. For a more intuitive judgment, the experimental team took cells from seven different organs from the two mice, and then compared them with the other two groups of mice, and analyzed and sequenced the differences.
Of course, there will be a problem here, how can it be impossible to distinguish the young organ cells in the old mice without special treatment, whether its original cells have changed, or whether the cells of young mice have run to this position through the circulatory system , thereby creating the illusion of youthfulness. To this end, the research team genotyped two mice in advance, so that it is clear at a glance whether the cells of the old mice themselves have changed.
After comparing the cells of seven different organs isolated, the research team found that the rejuvenation of the aged mice did come from the reversal of their own cells. The next thing that needs to be done is to analyze single cells, analyze and observe at the single molecular level, and re-validate the animals that show the effect of the factor. This also makes the discovery of young factors a huge and complex project.
In the following five years, the research team analyzed and sequenced 210,000 high-quality cells one by one, and found hundreds of different types of cell groupings. Finally, in such a huge target, a number of key factors for rejuvenation of aging cells were discovered, and two of the special youth-promoting factors attracted the special attention of the research team.
Because the researchers found that after treating the hematopoietic stem cells with these two special factors, they were able to make the hematopoietic stem cells appear younger. This finding also means that these two special factors can delay the aging rate of the entire hematopoietic system, and even the entire body.
The discovery of this youth-promoting factor not only fills the gap in related fields, but also directly promotes the further development of the body's anti-aging research. You must know that the "WLife" anti-aging substances mentioned above, as relatively mature technologies in related fields, cannot be popularized due to high costs. In the past ten years, only Musk, Bezos and Buffett can use them. Wait for the rich to enjoy. Even after the domestic "Lightweijian" biotechnology company was introduced to Jing-Dong for transformation, the cost dropped to four digits, which was not affordable for most groups after all.
I wonder if this new discovery of China Science, while filling the gaps in related fields, can promote the further development of the civilianization of anti-aging technology, and whether it will benefit more ordinary groups in the near future? Of course, the more direct impact of the current research findings is to provide valuable and solid single-cell data resources for the next development of related biological fields in China, laying a good foundation for subsequent research.
It is reported that this experimental result will be included in the "Aging Map Database" initiated by Chinese scholars. The data was initiated and established by Chinese scientists in two years. In just two years, it has been collected more than 140,000 times by researchers from 76 countries around the world. access. In addition to the data of relevant research in China, it also includes relevant research data from the United Kingdom, the United States, Italy and other countries. Unconsciously, the "aging map database" has become an academic benchmark in the field of anti-aging technology in the world.
The research results of the Chinese Academy of Sciences are not only a major progress in the field of biological anti-aging, but also provide a new boost for promoting the common development of all mankind. Under the premise of more and more abundant research data, it is believed that more mechanisms related to anti-aging will be discovered.