The life expectancy is extended by 40%, the US 'gene therapy' technology breakthrough, the mouth spray can be young
Zhuangzi said in "The Journey to the North" that "in the world of life, if a white horse crosses a gap, it will only happen suddenly". Creatures have appeared on the earth for 3.8 billion years. During this long period of time, any life can be passed down from generation to generation through reproduction. Is it possible to break the confinement of lifespan by changing genes?
American scientists can extend life by 41.4% through gene therapy
A team of American scientists found that "through gene therapy, life can be extended by 40%". The results were published in the international authoritative journal PNAS.
In order to explore different gene therapy methods, the researchers chose cytomegalovirus as a vector for gene therapy targeting telomeres and muscles. At the same time, two methods of new nasal inhalation and traditional intraperitoneal injection were used, allowing mice to receive gene therapy once a month from 18 months old (equivalent to about 56 years old in humans) for half a year to test the two differences. Efficacy of modality gene therapy. (plus telomeres, muscle)
Seven control groups were designed in the experiment to ensure the rigor of the experiment. The results showed that after half a year of gene therapy through the telomere pathway, the telomeres of the aged mice were extended by 6 times and the physiological age was halved. After gene therapy through the muscle route, the experimental mice were 33% stronger than members of the other groups, equivalent to 25% longer in young adults. The gene-treated mice lived 40 percent longer. During the course of the experiment, the life-extending effects of nasal inhalation and intraperitoneal injection were almost the same.
Gene therapy affects the lifespan of experimental subjects, and different treatment methods can achieve the same effect of prolonging lifespan. Professor Sinclair of the Harvard Laboratory exclaimed: The amazing effect of this gene therapy can prolong life by 40%. The traditional injection method is complicated and difficult to operate. In contrast, the therapeutic effect of nasal inhalation is not inferior at all, which is conducive to the popularization and application of this therapy.
Scientists uncover mechanism behind gene therapy
In fact, research on gene therapy has attracted the attention of the academic community for a long time. As early as 2012, Maria A Blasco, a famous Spanish scholar, used telomerase gene therapy to significantly improve aging markers such as telomeres in mice. animal state, and successfully increased the average lifespan of adult and aged mice by 24% and 13%, respectively. The scholar said: The reason for this result is that the mechanism behind it is the telomeres and mitochondria that cells rely on to survive.
"cell" has published a review article to explain the nine signs of human aging. Telomere shortening and mitochondrial dysfunction are two of them. Telomeres are called "life clocks" and are located at the end of chromosomes. It is getting shorter and shorter, until it is too short to be divided, and life is coming to an end. Research at Harvard University on the other side of the ocean has found that through the cell telomere mechanism, a series of survival problems caused by aging can be effectively alleviated. The related research results "Cele Rui" have been put into production. Similar to gene therapy, this substance also maintains the length of telomeres through cellular mechanisms, reversing telomeres to the state of youth, thereby prolonging old age. human health.
With the continuous development of scientific research, the mystery of human aging has been explored. Since the beginning of this century, life science and technology have developed rapidly, and the research on cells has become more in-depth, and the research on telomeres and mitochondria has won several scientists the Nobel Prize. Anti-aging scientific research has gradually moved closer to mainstream science, attracting the attention of many famous scientific research schools such as Harvard and Cambridge, and human clinical results have emerged. Celery, an anti-aging palace, is known as "oral stem cells" because of its good performance in protecting telomeres and mitochondria and other international biological aging indicators. However, due to its high price, it has caused criticism from users. The high price equivalent to the monthly income of ordinary people only makes it active in the high-end group.
Life expectancy may exceed 120 years old?
A cell can divide about 50 times on average, and each cell division cycle is about 2.4 years, and telomeres lose a certain length in each cell division. Based on this, American scientist Hayflick deduced that the normal lifespan of a person should be 50 × 2.4 years = 120 years old, which is the "Hayflick limit". The development of gene therapy may be expected to break Hayflick's limit.
Gene therapy can fight aging through cellular mechanisms, and the “nasal inhalation spray” method is painless, convenient and promising, and human clinical trials are underway. However, there are not a few anti-aging studies that have achieved results. The domestic front-end "Celeray" technology can achieve the same effect as gene therapy through cellular mechanisms. Because of its promising prospects in anti-aging, after entering J&D, it has met the needs of some groups. The hyperbaric oxygen chamber researched by Israeli scientists can also achieve the purpose of reversing the "life clock", but because of its high threshold, the mainstream civilian-level "o2ARK" is only open to experience in first-tier cities. With the continuous exploration of scientific research, anti-aging technologies such as "hyperbaric oxygen chamber" and "gene therapy" are also constantly maturing.
The development of biotechnology will provide new avenues for anti-aging research. Bank of America Merrill Lynch, a well-known Wall Street investment bank, said in the survey: Modern biotechnology is growing explosively at a rate of doubling in half a year, and it will not be long before I will enter the age of 100. Hayflick's limit theory will also be broken.