Gene editing to reverse aging? Singapore scientists: Reprogramming aging cells can extend lifespan by 31%
If genes can be reprogrammed, can our lives be programmed forever? As one of the important research directions in the field of life sciences, gene editing has always been regarded by scientists as a potential tool to reverse aging. From winning the Nobel Prize in Physiology or Medicine in 2012, to the Chinese Academy of Sciences developing a rapid and controllable "cocktail" cell editing to cultivate young human cells; the Cambridge laboratory reversed the skin cells of a 53-year-old person to 23 years old through transient gene editing. The explosion of blowout results has greatly increased the confidence of the academic community in it. A recent study from Yale University has once again ignited people's hopes.
A study published in the authoritative scientific journal "bioRxiv" pointed out that researchers from Yale University and the National University of Singapore have developed an upgraded version of the "transient reprogramming" technology based on the Nobel Prize-winning "cell reprogramming" technology. Successfully extended the lifespan of organisms by 31.6%.
Cell reprogramming combined with cell depletion, prolonging lifespan by 31.6%
Traditional cell reprogramming technology has certain defects. In the process of reversing cells, cell functions and characteristics will be lost, and there will be a risk of cancer. Researchers in Singapore have solved a series of problems caused by traditional reprogramming technology through transient reprogramming technology, making cells young while not reverting to a stem cell state, and not only has great potential in the field of anti-aging to be discovered, but also is expected to Treat age-related diseases.
The researchers chose fruit flies, which are highly similar to human genes, as experimental subjects. Gene editing of intestinal cells was realized by introducing "Yamanaka factor". On this basis, the researchers also used the method of removing aging cells to remove aging cells by interfering with proteins in the body. Although the use of the two alone can improve the intestinal cells, it speeds up the cell renewal cycle, and there is a risk of stem cell failure, and the combination of the two improves this problem to a certain extent.
After optimizing the experimental protocol, the researchers carried out multiple transient reprogramming and senescent cell clearance. The results showed that the death rate of the experimental subjects decreased, and the length of life was increased, and the combination of the two had the effect of prolonging life by 31.6%.
The anti-aging field under the blessing of capital is developing rapidly
Rewriting lifespan through cell reprogramming technology is not new in the capital world. Bezos, the former richest man in the world, has invested hundreds of millions in the biotechnology company alto labs, whose main research is cell reprogramming. Not long ago, they also released experimental results, directly "gene editing" in vivo, and their senescent cells successfully achieved reverse growth after 7 months.
The researchers are currently exploring the safety factor of the research method, and have determined whether it could one day be used to delay aging in other mammals, including humans. The middle-aged and elderly wealthy people have long been fidgeting, hoping to rewrite the process of cell aging through the "oral stem cell" technology of Celery. In the experiment, Professor Sinclair of Harvard University supplemented this substance for a 65-year-old man for three consecutive months. As a result, the standards of the subjects, including the mitochondria of cell vitality indicators, returned to a younger level. However, the same criticism as "genetic programming" is that Sailorui has also been criticized by high-net-worth groups such as Lidong because of its high price. "A bottle is equivalent to the monthly salary of ordinary migrant workers! of."
In addition, there is no shortage of capital behind numerous anti-aging research. Moreover, many scientific researches have been transformed into results. Li Ka-shing, the richest man in real estate in the world, once invested 30 million yuan in the development of relevant technical products in the American Bio-Anti-aging Company. Although the effect is far inferior to that of Celeria, Li lamented that "the body returned to 20 years old" after taking it.
Against the backdrop of an aging society, anti-aging research is gaining more and more attention
Japan's most influential English-language newspaper "The Japan Times" reprinted a commentary article "Aging Is the Next Global Economic Threat" by Noah Smith, a Bloomberg columnist and professor of finance at Stony Brook University. The article analyzed aging from various aspects. a series of problems brought about by The article points out: Society has never experienced long-term sustained aging. Countries need to continue to actively seek solutions.
In addition to epigenetic reprogramming, finding ways to resist aging through different methods seems to have become the consensus of the rich. There are studies on NAD+ precursors that have produced several Nobel Prizes, research on calorie restriction that spans centuries, and more blood exchanges , freezing and other extreme methods, no matter what kind of way is to seek to prolong the length of healthy life. The prolongation of life span not only involves individual genetic factors, but also is closely related to the development of civilization and medical science and technology. The time of human existence is only a moment in the history of the earth, but genes can be passed down from generation to generation. Whether it can extend the length of life through cell compilation remains to be considered.